I've been running Vista on my laptop for a couple of weeks and generally love it. Last week at the ASPInsiders meeting I made the rather unurprising discovery that Vista comes with IIS7, so was looking forward to playing with it more. As ever I've not had time, but have just hit my first IIS7 problem, which could affect many people developing ASP.NET applications on Vista - Vista and IIS7 does not have a local SMTP server. That means anyone using SMTP to deliver mail (we use it for automated error reports) will receive a "transport not present" error, no doubt spending a ton of time looking for the solution.
Christoph has suggested I try MailEnable, which will at least solve the immediate problem.